Welcome to Canary Journal
Our mission is to support the community of researchers dedicated to improving early detection of cancer. This website is a repository of published scientific papers and news as well as a forum for discussion and debate about advancements and issues in the field of cancer early detection. We hope to foster communication among scientists in all the diverse disciplines that contribute to this field.
Canary Journal is still under development and is soliciting feedback on ways to increase our usefulness to the scientific community. We are interested in ways to improve our database of published content as well as ideas for original content that would be valuable to the early detection community. Please take a look around the website and tell us what you think by contacting the editor directly. Thank you for your help.
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Recent News Articles
Many older men still get prostate cancer testing
Fox News: April 27, 2012
Lung cancer screenings ‘a good value,’ study finds
Los Angeles Times: April 10, 2012
Breast Cancer: Women With False Positive Mammograms at Higher Risk
ABC News: April 5, 2012
Recent Papers
Field cancerization in non-small cell lung cancer: implications in disease pathogenesis.
Authors: Kadara, Humam; Wistuba, Ignacio I
Citation: Proc Am Thorac Soc 2012; 9(2):38-42
Lung cancer, of which non-small cell lung cancer (NSCLC) composes the majority, is the leading cause of cancer-related deaths in the United States and worldwide. NSCLCs are tumors with complex biology that we have recently started to understand with the advent of various histological, transcriptomic, genomic, and proteomic technologies. However, the histological and molecular pathogenesis of this malignancy, in particular of adenocarcinomas, is still largely unknown. Earlier studies have highlighted a field cancerization phenomenon in which histologically normal-appearing tissue adjacent to neoplastic and pre-neoplastic lesions display molecular abnormalities, some of which are in common with those in the tumors. This review will summarize advances in understanding the field cancerization phenomenon and the potential relevance of this knowledge to gain important and novel insights into the molecular pathogenesis of NSCLC as well as to subsequent development of biomarkers for early detection of lung cancers and possibly personalized prevention.
Epigenetic Biomarkers in Lung Cancer.
Authors: Liloglou, Triantafillos; Bediaga, Naiara G; Brown, Benjamin; Field, John K; Davies, Michael Pa
Citation: Cancer Lett 2012
Lung cancer mortality is strongly associated with the predominant diagnosis of late stage lesions that hampers effective therapy. Molecular biomarkers for early lung cancer detection is an unmet public health need and the lung cancer research community worldwide is putting a lot of effort to utilise major lung cancer population programmes in order to develop such molecular tools. The study of cancer epigenetics in the last decade has radically altered our views in cancer pathogenesis, providing new insights in biomarker development for risk assessment, early detection and therapeutic stratification. DNA methylation and miRNAs have rapidly emerged as potential biomarkers in body fluids showing promise to assist the clinical management of lung cancer. These new developments are exemplified in this review, demonstrating the huge potential of clinical cancer epigenetics, but also critically discussing the necessary validation steps to bring epigenetic biomarkers towards clinical implementation and the weaknesses of current biomarker studies.
Genetic biomarkers of cancer risk.
Authors: Calzone, Kathleen A
Citation: Semin Oncol Nurs 2012; 28(2):122-8
OBJECTIVES: To provide a review of genetic biomarkers of cancer risk and associated clinical implications. DATA SOURCES: Published literature, evidence-based guidelines. CONCLUSION: Identification of the genetic variation associated with cancer risk enables the health care provider to stratify an individual’s risk and personalize their cancer risk management. This may lead to a decreased cancer incidence in high-risk populations, but at a minimum, will provide the opportunity for early diagnosis that may decrease cancer morbidity and mortality. IMPLICATIONS FOR NURSING PRACTICE: Nursing implications include assessment for cancer risk, initiate referrals indicated, and delivering ongoing education and support for cancer risk management plans.
